Véronique L. Roger, M.D.
Alanna M. Chamberlain, Ph.D.
- Aim 1: To examine the associations of negative affect (depression, hostility and anger) with measures of inflammation (white blood cell count and high-sensitivity C-reactive protein) in African Americans. In doing so, we will test the hypothesis that measures of negative affect are correlated with increased levels of inflammatory markers in African Americans.
- Aim 2: To examine the associations of depression, hostility and anger with incident HF and to test the hypothesis that these psychosocial constructs are associated with the development of HF among African Americans after controlling for traditional HF risk factors. Identification of unique factors contributing to the racial disparity in HF is a key step to identifying future areas of research and interventions to reduce the excess burden of HF in African Americans.
The results of this study will provide preliminary data supporting submission for extramural funding to more comprehensively investigator factors contributing to the excess burden of HF in African Americans, an area of research that is urgently needed.